01 - Season beef chunks evenly with salt and black pepper.
02 - Heat olive oil in a large skillet over medium-high heat. Brown beef on all sides, approximately 5 minutes. Transfer browned beef to slow cooker.
03 - In the same skillet, sauté onion, carrots, and celery for 4 to 5 minutes until softened. Add garlic and cook an additional minute. Transfer mixture to slow cooker.
04 - Pour red wine into skillet; simmer for 2 minutes, scraping browned bits from the pan. Add wine and remaining ingredients including crushed tomatoes, tomato paste, beef broth, oregano, thyme, bay leaves, and red pepper flakes to slow cooker. Stir well.
05 - Cover and cook on low for 8 hours until beef is tender and shreds easily.
06 - Remove bay leaves. Using two forks, shred beef directly in slow cooker; stir to combine. Taste and adjust seasoning as necessary.
07 - Approximately 20 minutes before serving, prepare pappardelle according to package instructions. Drain and set aside.
08 - Plate pappardelle topped with beef ragu. Garnish with grated Parmesan cheese and fresh basil.